Knime4Bio is a set of nodes for KNIME used to analyse data produced by the next-generation-sequencing (NGS) technologies. Most of the nodes are used to filter and annotate VCF (Variant Call Format) files, some nodes can be used to query the NCBI databases, the mysql ucsc server, etc...
The main site for KNIME4Bio is http://code.google.com/p/knime4bio/
Knime4Bio: a set of custom nodes for the interpretation of Next Generation Sequencing data with KNIME.: http://bioinformatics.oxfordjournals.org/content/early/2011/10/07/bioinformatics.btr554.abstract. Pierre Lindenbaum, Solena Le Scouarnec, Vincent Portero and Richard Redon